Targets of Drug Actions in CNS
Drug mainly targets enzymes and receptor regions in the form of proteins and nucleic acid in which activities can be modified relatedly by a dosage regimen i.e. drug whose activity can be modified by a drug. The drug could be a low-molecular weight chemically inert compound or a biological compound as a recombinant protein or an antibody. The targets of Drug should show chemical, mechanical and biological responses including their in-vitro and in-vivo methods relevant to diseases. Whereas the main Neurotransmitters during the process of Neurotransmission, chemical targets includes mainly GABA, Glutamate etc. that operates through functioning of Neuromodulators like 5 Epinephrine, Prostanoids, 5-Hydroxy tryptamine, Acetylcholine that acts through both ligand gated channels and G-protein coupled receptors. Function as both Neuromodulator and Neurotransmitter. Lipid Solubility and Binding sites are the factors for chemical signalling variations; Intracellular receptors occupy hydrophobic chemical signals to cell surfaces. Agonists and Antagonists modify receptor activity. Chemical signalling in CNS takes place through blood or other fluids but is slow in functioning process. The cell body, dendrites, axon are the major regions for integration of signals in neuronal and organelle regions.